Zimmer | DeNovo NT Natural Tissue Graft | Which Medical Device
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Articular cartilage repair
From Which Medical Device
This product consists of particulated natural (ie human allograft) articular cartilage containing living cells and derived from donors under 13 years of age. It is intended for focal articular cartilage defects, and the product is fixed with fibrin, therefore not requiring a periosteal flap.
The publication of a case report lead to a press release on the effectiveness of the technique in March 2011(1). In this case, a 36 year old man with a focal defect of the articular cartilage of the patella saw resolution of his symptoms and MRI findings at 2 years postoperatively. An ongoing clinical trial is set to complete primary outcome data collection in 2013.
Other strategies for the treatment of cartilage defects include mosaicplasty, autologous chondrocyte implantation or tissue engineered cartilage constructs in which autologous chondrocytes are implanted in conjunction with collagen or fibrin glue.
References:
1. Bonner KF, Daner W, Yao JQ. 2-year postoperative evaluation of a patient with a symptomatic full-thickness patellar cartilage defect repaired with particulated juvenile cartilage tissue.J Knee Surg. 2010 Jun;23(2):109-14.
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